HIV in children. Dr Trisha Macnair  

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Most children with the disease are infected in the womb or during birth.

What is HIV?

Human immunodeficiency virus (HIV) is an infection that causes acquired immunodeficiency syndrome (AIDS), a chronic, life-threatening condition.

AIDS occurs when the HIV infection damages or destroys the cells of the immune system, reducing the body's ability to fight off bacterial, viral and fungal infections.

As the immune system fails, the person becomes vulnerable to illnesses they would normally resist (known as opportunistic infections), such as pneumonia, meningitis, intestinal infection and certain types of cancers.

HIV in children is uncommon in Europe and the UK. However, it is estimated that over 2 million children worldwide have HIV, most of them are in sub-Saharan Africa.

Symptoms

The initial infection with HIV may cause a brief flu-like illness two to six weeks after infection, with symptoms such as fever, headache, sore throat and swollen lymph glands.

However, many people don't show any particular symptoms and children are often infected while in the womb.

There appear to be two general patterns of illness in HIV-infected children.

  • About 20 per cent develop serious disease in the first year of life, most of whom die by the age of four
  • In the remaining 80 per cent, the disease progresses more slowly

Children with HIV often fail to gain weight and don't grow properly. They may develop problems with walking, or show delayed mental development.

Like adults, children are vulnerable to opportunistic infections and normal childhood infections can be severe.Link...

You are what you eat  

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A good diet is central to overall good health, but which are the best foods to include in your meals, and which ones are best avoided? This section looks at the facts, to help you make realistic, informed choices.Link...

Sexual health  

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It's important to pay attention to your sexual health if you're in a relationship. Find out about sexual health screening, contraceptive methods and sexually transmitted infections.Link...

Lung cancer genetics unravelled  

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The genetics underpinning a smoker's risk of developing lung cancer have been further unpicked by UK scientists.

Three areas of DNA were found to be linked with lung cancer risk in smokers - two of them influencing the type of cancer which develops.

It supports previous studies which have suggested a family link, even after taking smoking into account, a report in the Cancer Research journal says.

Smoking is responsible for nine out of 10 cases of lung cancer.

The Institute of Cancer Research team compared the DNA of 1,900 lung cancer patients and 1,400 healthy individuals.

The best thing a smoker can do to reduce their risk of lung cancer, and a range of other life-threatening conditions, is to quit
Dr Lesley Walker, Cancer Research UK

Information gathered on areas of genetic risk was then tested further in another 2,000 patients with lung cancer and a similar number of healthy volunteers.

Specific differences associated with lung cancer risk were found on chromosomes 5, 6 and 15.

Those with certain genetic changes on chromosome 5 were more likely to get a type of cancer called adenocarcinoma and the region highlighted on chromosome 6 seemed to influence whether a patient developed adenocarcinoma or another type called squamous cell carcinoma.

On chromosome 15, they pinpointed two independent sites that have a role in whether or not a smoker develops lung cancer.

These areas of the genome contain a family of genes that influence smoking behaviour but also cell growth and cell death.

Current or former smokers who carry one copy of each of these genetic variants increase their risk of lung cancer by 28%.

That increases to 80% in smokers who carry two copies.

Those who had the genetic changes but did not smoke had no increased risk of lung cancer.

Trigger

Study leader Professor Richard Houlston said the findings confirmed earlier research.

"The next step is to dig deeper to pinpoint which gene, or genes in these regions, cause the increased risk of developing lung cancer and how they actually trigger this increase."

Dr Lesley Walker, director of cancer information at Cancer Research UK who partly funded the research, said smoking was responsible for the vast majority of lung cancers.

"This research shows that inherited genetic variation accounts for some of this risk and the type of lung cancer that develops."

She added: "The best thing a smoker can do to reduce their risk of lung cancer, and a range of other life-threatening conditions, is to quit."

Dr Noemi Eiser, honorary medical director of the British Lung Foundation, said: "This research is very interesting as it provides further clues as to why some smokers are more prone to developing certain types of lung cancer.

"We now hope that with more research this discovery will lead to the development of early screening techniques and treatments for lung cancer, which is currently the UK's biggest cancer killer."Link...

Deaths from HIV in the US Continue to Decli  

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October 24, 2030 - For the first time in 45 years the number of deaths from HIV in the US will be below 5,500 this year. Since the peak in 1995 when almost 55,000 people gave in for the disease, casualties have declined.

The reason for the declining mortality from human immunodeficiency virus (HIV) is due to more knowledge among the general population of how to be protected against the disease, and the availability of more effective highly active anti-retroviral therapy (HAART). The last decades have seen progress in the developing of medicines to treat AIDS however there is no definite cure in sight.

Even though these numbers for the US are satisfying, AIDS has globally been outstanding in causing more deaths than any other epidemic, now counting more than 180 million people worldwide since it was recognized in year 1981. The projected life expectancy rate at birth are now five years lower in the whole of Africa, and the population is 280 million lower, than it would have been without the occurrence of AIDS.

Argument: According to the study Comparing The Public Health Burden of Chronic Hepatitis C and HIV Infection in United States, deaths from HIV in the US will be 4,200-6,700 in year 2030. The numbers of deaths worldwide from AIDS have been published by the United Nations in the report The Impact of AIDS.

Questions: The human population will be 3.5% lower in year 2030 than it would have been without the occurrence of AIDS and even if a cure is found, more than 40 million people will die before the epidemic is extinct. What is the loss of value for humanity to loose such a big part of the population? Can that value be invested today to prevent the disease to spread further?

16 Million New Cancer Cases Worldwide  

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November 15, 2020 - The number of new cases of cancer this year will exceed 16 million worldwide for the first time. This is an increase with 60% compared to 20 years ago and is due to the growing and aging population, and adoption of unhealthy lifestyles.

Tobacco is still the biggest single source for developing malignant tumors and lung cancer the most common form of cancer. The relative risk for a regular smoker to develop lung cancer compared to a non-smoker is between 20 and 30 times higher. Even involuntary tobacco smoke may increase the lung cancer risk by 20 percent.

The connection between smoking and lung cancer was already established in a report in 1957. They then estimated that the mortality rate caused by lung cancer had doubled from 1945 to 1955. Today, more than 10 million people worldwide dies from smoking every year.

The best way to avoid getting cancer is staying away from cancer-causing agents like tobacco and industrial carcinogens. It is also important to stay healthy with physical activity, and in general avoid fat food, refined carbohydrates and animal protein. Since there is still no cure for cancer, the best way to deal with cancer is early detection. In that way patients can start treatment as soon as possible which gives a lower mortality rate.

Argument: WHO has revised their World Cancer Report to 16 million new cases of cancer in the world by year 2020.

Questions: Since the cost for treating cancer in the US only, is more than US$ 170 billion a year and tobacco is the single biggest source, how much would it be worth in preventing young people from starting to smoke to save money in the future? Should governments go in to the market and offer a substitute for tobacco to drive the tobacco companies of the market with a substance that is less risky and expensive for the citizens?

More People in the US Suffer from Atrial Fibrillation  

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May 16, 2050 - More than 5.6 million people in the US will be diagnosed with atrial fibrillation this year, compared to 2.3 million 50 years ago.

The main reason for the increase is the aging population, and half of the people suffering from atrial fibrillation are 80 years or older.

Atrial fibrillation occurs when the blood is not pumped out properly of the heart's two upper chambers (atria), which eventually can make it clot. About 15 percent of strokes occur when such clot from the atria becomes lodged in the artery in the brain.

Argument: According to the study Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation, between 5.0 and 6.3 million people in the US are projected to be diagnosed with atrial fibrillation.

Deadly Skin Cancer More Common in the UK  

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June 20, 2035 - This year more than 21,000 people in the UK will be diagnosed with malignant melanoma - the deadliest form of skin cancer - which is three times as many as 30 years ago. The reason for the increase is the global warming and that more people in the UK travel abroad to sunnier locations.

Most skin cancers are easily treatable and unlikely to spread, and are called non-melanoma. Malignant melanoma is the most serious type of the disease and may be fatal. It is more common in women than men and research says that sunburns in childhood can double the risk of melanoma in later life.

Some people are born with a greater risk of skin cancer than others. These people tend to burn easily, have fair skin and/or freckles, have red or fair hair and/or pale eyes, have a large number of moles (50+), or have skin cancer in the family (especially melanoma). If one or more of these descriptions apply to you, you should take extra care to protect yourself from the sun.

180 Million Deaths Worldwide from HIV  

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June 26, 2030 - The total number of deaths from HIV/AIDS worldwide is now said to have passed 180 million people, since it was recognized 50 years ago. The most infected are to find in sub-Saharan Africa and Asia.

AIDS is the worst pandemic ever to have hit mankind, and have caused more deaths than the Spanish Flu in 1918-1919 and the Black Death in the 14th century combined. Well, you can add the deaths caused directly by the two world wars during the 20th century too, and AIDS will still outnumber them all. More than half of the deaths from HIV originates from the sub-Saharan Africa, where there now are 14% fewer inhabitants than it would have been without the occurrence of AIDS.

Even though the deaths are tragic, living with the disease put a lot of strain on the average household. The affected families are losing income, as well as get higher expenditure for medical treatment, which impoverish households even further in an already poor part of the world. This forces many families to reduce the consumption of food, which results in malnutrition for all members of the family.

The efforts to raise awareness among the most affected populations have been quite successful during the last decades, as well as lowering the cost for the medicine needed to treat the disease, but there is still no definite cure in sight.

Argument: The numbers of deaths worldwide from AIDS published by the United Nations in the report The Impact of AIDS for year 2025 have been revised for the year 2030.

Questions: What consequences will this loss of human lives have for the strive towards stability in the poor parts of the world?

370 Million People Worldwide Suffer from Diabetes  

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August 1, 2030 - New statistics suggest that more than 370 million people worldwide today suffer from diabetes. The numbers have doubled over the last 30 years. Much of this increase has taken place in developed countries, due to ageing, obesity, unhealthy diets, population growth and sedentary lifestyles.

The direct costs for treating diabetes will only for the US this year be about US$ 506 billion. Although the number of people dying directly from diabetes is approximately 1.5 million worldwide, the number of deaths every year attributable to complications of diabetes is more than 8 million.

Even though improvements have been made in the work for finding a permanent cure for diabetes, the best cure for type-2 diabetes (which results from the body's inability to respond properly to the action of insulin produced by the pancreas) which accounts for about 90% of the cases, is still to exercise and keep a healthy diet. A 30 minute walk each day reduces the incidence of diabetes.

Argument: WHO estimates that 370 million people worldwide will suffer from diabetes in 2030, compared to 177 million in 2000. The figure US$ 506 billion in direct costs for the US to treat diabetes is based on today's cost, the estimated inflation and increase in patients to treat. No eventual cure for diabetes until 2030 is considered. Today the most permanent method of treating diabetes is a pancreas transplant which gives the patient a chance to become independent of insulin injections.

Questions: The most promising cure for diabetes is based on stem cell research. How much of the estimated cost for diabetes in 2030 would be worth investing today to get closer to a cure and what would be the return on that investment? Since physical activity reduces the incidence of diabetes, how much is worth investing in people being more active, already from a young age and to keep them active on a regular basis?